「case078」の編集履歴（バックアップ）一覧はこちら
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<div class="Section1">
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt"><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ ゴシック"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
制酸薬</span><font face="Century"><span lang="EN-US" style=
"FONT-SIZE: 9pt; mso-fareast-font-family: "ＭＳ ゴシック"">:</span>
</font><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">制酸薬</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">H2</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">ブロッカーや</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">PPI</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">など強力な胃酸抑制薬が登場した現在でも</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
急性胃炎や</span> <span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">Non Ulcer dyspepsia (NUD)</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
などに速効性を期待して急性期に短期間用いられる</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
重曹</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face="Century">,
Mg</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">, Al</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤がある</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">. Al</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤は制酸力は弱いが</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
粘膜保護作用</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
ペプシン不活化作用を有する</span><span lang="EN-US" style=
"FONT-SIZE: 9pt"><font face="Century">.</font></span> <u><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
アルミゲルと水酸化マグネシウムを配合した<b style=
"mso-bidi-font-weight: normal">マーロックス</b></span></u><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">などは即効性があり</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
胃炎</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
逆流性食道炎</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
消化管出血に液剤および懸濁用顆粒として広く用いられるが</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
腎障害患者では高</span><span lang="EN-US" style=
"FONT-SIZE: 9pt"><font face="Century">Mg</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">血症に注意する</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
また</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
テトラサイクリン</span><span lang="EN-US" style=
"FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
ニューキノロン系などの吸収を阻害するため併用しない</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
また</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face="Century">,
Al</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤では便秘を</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
逆に</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">Mg</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤では下痢をきたしやすい</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">吸収性の製剤ではアルカローシスとなるほか</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">, Al</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤はリン酸と結合して不溶性の塩を形成し低リン血症を生じるため</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
長期連用時には骨軟化症に注意する</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
アルミニウム脳症は腎不全がない症例でも注意すべきであり</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
漫然とした</span><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">Al</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">製剤の長期投与は控える</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.<br></font></span></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt; TEXT-ALIGN: right" align=
"right"><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">[</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">今日の治療薬</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">2005]<br></font></span></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt"></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt"><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ ゴシック"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
アルミニウム骨症</span> <span style="FONT-SIZE: 9pt"><font face=
"Century"><b style="mso-bidi-font-weight: normal"><span lang="EN-US">aluminium
osteodystrophy</span></b><span lang="EN-US">:</span></font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
腎不全に特有な骨の障害</span> <span lang="EN-US" style=
"FONT-SIZE: 9pt"><font face="Century">(</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">腎性骨症</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">)</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
の一つで，アルミニウムが骨に沈着して骨軟化症的な変化を生じるものをいう</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
腎不全では体内に取り込まれたアルミニウムは腎機能の廃絶に伴い腎臓より排泄できないために体内に蓄積する</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
特に血液透析患者では透析液中に含まれるアルミニウム</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
リン結合薬として使用されたアルミニウム製剤，あるいは日常生活の飲食物から負荷されるアルミニウムが体内に貯留し</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
アルミニウム中毒を招くことが知られている</span><span lang=
"EN-US" style="FONT-SIZE: 9pt"><font face="Century">.</font></span>
<span style="FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
脳に沈着すると</span><span lang="EN-US" style=
"FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ ゴシック"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
アルミニウム脳症</span><font face="Century"><b style=
"mso-bidi-font-weight: normal"><span lang="EN-US" style=
"FONT-SIZE: 9pt">aluminium encephalopath</span></b><span lang="EN-US" style=
"FONT-SIZE: 9pt">y</span></font><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">となり</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">,</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
骨に沈着するとアルミニウム骨症となる</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">.</font></span> <span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
骨に沈着したアルミニウムはデスフォリオキサミン治療により除去することができる．</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><br></span></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt; TEXT-ALIGN: right" align=
"right"><span lang="EN-US" style="FONT-SIZE: 9pt"><font face=
"Century">[</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">南山堂医学大辞典第</span><span lang="EN-US"
style="FONT-SIZE: 9pt"><font face="Century">18</font></span><span style=
"FONT-SIZE: 9pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">版</span><font face="Century"><span lang="EN-US"
style="FONT-SIZE: 9pt">]</span><span lang="EN-US" style=
"FONT-SIZE: 10pt"><br></span></font></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt"></p>
<p class="MsoNormal" style="MARGIN: 0mm 0mm 0pt"><span style=
"FONT-SIZE: 10pt; FONT-FAMILY: "ＭＳ 明朝"; mso-ascii-font-family: Century; mso-hansi-font-family: Century">
片頭痛</span><span lang="EN-US" style="FONT-SIZE: 10pt"><br></span></p>
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